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By Philip S. Mellor, Matthew Baylis, Christopher Hamblin, Charles H. Calisher, Peter P.C. Mertens
African horse disease virus is a double-stranded RNA virus which reasons a non-contagious, infectious arthropod-borne affliction of equines and sometimes canine. 9 specified, the world over known serotypes of the virus have to this point been pointed out. This booklet is predicated upon the findings of 2 programmes funded via the eu fee. will probably be of worth not just to the professional learn employees but in addition to veterinary employees facing keep watch over and to legislators looking to advertise secure overseas circulate of equines. the subjects lined contain cutting-edge discussions on diagnostics, vaccines, molecular biology, vector reports, and epidemiology.
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Extra info for African Horse Sickness
Med Vet Entomolll: 203-212 2. Hamblin C, Graham SD, Anderson EC, Crowther JC (1990) A competitive ELISA for the detection of group-specific antibodies to African horse sickness virus. Epidemiol Infect 104: 303-312 3. Hamblin C, Salt JS, Mellor PS, Graham SD, Smith PR, Wohlsein P (1998) Donkeys as a reservoir of African horse sickness. In: Mellor PS, Baylis M, Hamblin C, Calis her CH, Mertens PPC (eds) African horse sickness. Springer, Wien New York, pp 37-47 (Arch Virol [Suppl] 14) 4. Hasnaoui H, Harrak M, Tber A, Fikri A, Laghzaoui K, Bikour MH (1998) Application of an indirect fluorescent antibody assay for the detection of African horse sickness virus antibodies.
Discussion The serotypes of AHS virus were not distributed independently in this zebra population but the cause cannot be determined from these data. Several mechanisms could generate the patterns observed here, such as facilitation, crossreactive immunity or heterogeneity in host-vector transmission rates. e. biological interactions between serotypes. Facilitation can act in two ways, either sequentially or simultaneously, and would lead to positive associations between specific serotypes. If infection with one serotype increases susceptibility to another serotype, sequential facilitation is present.
The titres of AHSV-specific neutralising antibodies and the number of immune cells were also significantly lower than in immunocompetent animals. Our findings suggest that donkeys may be able to playa role in the epidemiology of AHS but the ability of vectors to become infected by feeding upon viraemic donkeys needs to be assessed before the significance of that role can be fully understood. Introduction During epizootic periods in Spain (1987-1990) and Morocco (1989-1991) cases of African horse sickness (AHS) were observed from June to early December, alternating with periods of apparent quiescence from December to May [9, 10].
African Horse Sickness by Philip S. Mellor, Matthew Baylis, Christopher Hamblin, Charles H. Calisher, Peter P.C. Mertens