Download e-book for kindle: Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio
By Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)
Adrenomedullin was once stumbled on in 1993 in an extract of human pheochromocytoma whereas tracking cAMP degrees in rat platelets. Adrenomedullin has attracted substantial curiosity between cardiologists as a result of its effect at the cardiovascular approach which incorporates a lessen in blood strain in vivo; an influence on vascular gentle muscle cells; raises cAMP degrees; not directly reduces blood strain and has a task within the pathogenesis of arteriosclerosis.
Adrenomedullin in heart problems is an up to date evaluation of the main proper facets of adrenomedullin. It incorporates a wide variety of fields together with biochemistry, molecular biology, body structure, pharmacology, pathophysiology of heart problems and medical purposes of adrenomedullin to cardiovascular disease.
Toshio Nishikimi, MD, PhD, is an affiliate Professor within the division of high blood pressure and Cardiorenal medication, Dokkyo collage university of medication, Tochigi, Japan.
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9. UNKNOWN SIGNAL TRANSDUCTION PATHWAY(S) FOR APOPTOSIS AND MIGRATION (1) ANTI-APOPTOTIC EFFECT After serum-deprivation, endothelial cells undergo apoptosis. , 1997), although it has no mitogenic effect. Neutralization experiment using anti-AM antibody revealed a marked enhancement of endothelial apoptosis after serum starvation. , 1997). , 1997), suggesting that AM exerts its anti-apoptotic effect through the mechanism independent of cAMP/PKA pathway. , 1999). , 2002). , 1998). In serumstarved quiescent RAECs, AM upregulates Max gene expression without affecting Myc gene expression, thereby leading to the increased Max/Myc ratio.
1997) The interaction of CGRP and adrenomedullin with a receptor expressed in the rat pulmonary vascular endothelium. J Mol Endocrinol 18:267-272. Hausdorff WP, Bouvier M, ODowd BF, Irons GP, Caron MG, and Lefkowitz RJ. (1989) Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem 264:12657-12665. Hilairet S, Foord SM, Marshall FH, and Bouvier M. (2001) Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins.
2002). , 2000), and Cormier-Regard et al. , 1998). The 5'-flanking region of the human AM gene also contains this HIF-1 consensus sequence at nudeotides -825, -863 and -1203. , 2002). This pathway has been shown to be common with the signal transduction system of inflammatory stimuli such as IL-1. As to the pathophysiological implication of AM induced by ischemia and hypoxia, Wang et al. , 1995). Thus, the increased AM may dilate focal blood vessels and thereby serve to restore blood flow to the ischemic tissue.
Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)